摘要
胃食管反流病是消化系统常见病,中医药治疗胃食管反流病获得良好疗效.该研究从血清学指标及相关通路角度总结中医药治疗胃食管反流病的疗效机制,常见的血清学因子可分为神经递质、胃肠激素、炎症介质三大类,通过恢复食管下括约肌功能、调控内脏高敏感、改善食管黏膜炎症三大途径来干预胃食管反流病进展.其中恢复食管下括约肌功能的血清学物质主要有胃泌素、胃动素、血管活性肠肽、胆囊收缩素等,通过SCF/c-kit信号通路、PLC-DAG-PKC信号通路等发挥作用.调控内脏高敏感的血清学物质主要有P物质、CGRP、5-羟色胺等,通过基于TRPV1蛋白相关因子、MC-PAR2-TRPV1信号通路等发挥作用.改善食管黏膜炎症的血清学物质主要有白细胞介素-18、白细胞介素-6、白细胞介素-1β、肿瘤坏死因子-α、C反应蛋白等,通过TLR4/NF-κB、NF-κB、NLRP3/Caspase-1等通路发挥作用.部分血清学因子对GERD机制呈现互相协同,或多途径作用的效果.该研究为胃食管反流病的研究提供了参考.
Abstract
Gastroesophageal reflux disease(GRED)is a common disease of the digestive system,and traditional Chinese medicine has achieved good results in treating GRED.This study summarizes the therapeutic mechanism of traditional Chinese medicine in the treatment of GRED from the perspective of serological indicators and related pathways.Common serological factors can be divided into three categories:neurotransmitters,gastrointestinal hormones,and inflammatory mediators.By restoring the lower esophageal sphincter,there are three major ways to intervene in the progression of GRED:function,regulating visceral hypersensitivity,and improving esophageal mucosal inflammation.Among them,the serological substances that restore the function of the lower esophageal sphincter mainly include gastrin,motilin,vasoactive intestinal peptide,cholecystokinin,etc.,which work through the SCF/c-kit signaling pathway,PLC-DAG-PKC signaling pathway,etc.Serological substances that regulate visceral hypersensitivity mainly include substance P,CGRP,5-hydroxytryptamine etc.,which work through TRPV1 protein-related factors,MC-PAR2-TRPV1 signaling pathways etc.Serum substances that improve esophageal mucosal inflammation mainly include IL-1 8,IL-6,IL-1β,tumor necrosis factor-α,C-reactive protein etc.,through TLR4/NF-κB,NF-κB,NLRP3/Caspase-1 etc.pathways function.Some serological factors have synergistic or multi-pathway effects on the mechanism of GERD.This study provides a reference for the study of GRED.
维普
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