Analysis of Serological Factors and Mechanism Pathways of Traditional Chinese Medicine in the Treatment of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease(GRED)is a common disease of the digestive system,and traditional Chinese medicine has achieved good results in treating GRED.This study summarizes the therapeutic mechanism of traditional Chinese medicine in the treatment of GRED from the perspective of serological indicators and related pathways.Common serological factors can be divided into three categories:neurotransmitters,gastrointestinal hormones,and inflammatory mediators.By restoring the lower esophageal sphincter,there are three major ways to intervene in the progression of GRED:function,regulating visceral hypersensitivity,and improving esophageal mucosal inflammation.Among them,the serological substances that restore the function of the lower esophageal sphincter mainly include gastrin,motilin,vasoactive intestinal peptide,cholecystokinin,etc.,which work through the SCF/c-kit signaling pathway,PLC-DAG-PKC signaling pathway,etc.Serological substances that regulate visceral hypersensitivity mainly include substance P,CGRP,5-hydroxytryptamine etc.,which work through TRPV1 protein-related factors,MC-PAR2-TRPV1 signaling pathways etc.Serum substances that improve esophageal mucosal inflammation mainly include IL-1 8,IL-6,IL-1β,tumor necrosis factor-α,C-reactive protein etc.,through TLR4/NF-κB,NF-κB,NLRP3/Caspase-1 etc.pathways function.Some serological factors have synergistic or multi-pathway effects on the mechanism of GERD.This study provides a reference for the study of GRED.
traditional Chinese medicinegastroesophageal reflux diseaseserological factorspathwaysmechanisms
万方数据
维普
