Research Progress on the Dual Effects of Microglia on Intracerebral Hemorrhage
Intracerebral hemorrhage has the characteristics of high incidence,high disability rate and high fatality rate,which has caused a heavy burden to the family and society.As a resident immune cell of the central nervous system,the activation of microglia plays a dual role in tissue damage after intracerebral hemorrhage.The damage in intracerebral hemorrhage is reflected in the following aspects:releasing inflammatory factors,promoting programmed cell death,producing glutamate to induce excitotoxicity,destroying the blood-brain barrier,producing reactive oxygen species to induce oxidative stress,and aggravating brain edema.The protective effect is reflected in the phagocytosis and clearance of hematoma by microglia,the promotion of angiogenesis,and the secretion of anti-inflammatory and neurotrophic factors.This article summarizes the function of microglia and its dual regulatory mechanism in intracerebral hemorrhage.In the future,drugs,acupuncture and other clinical treatments can be used to intervene in the activation state of microglia,so as to reduce the harm of microglia.
intracerebral hemorrhagemicrogliainflammationprogrammed cell death
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维普
