The structural changes of intestinal flora will increase the expression of inflammatory cytokines and damage the immune system of the body,which will lead to insulin resistance(IR)and the production of type 2 diabetes mellitus(T2DM).This article analyzed the correlation between intestinal flora and insulin resistance and type 2 diabetes mellitus,discussed the mechanism of probiotics to improve IR and T2DM,elaborated the research progress of probiotics combined application on improving insulin resistance and type 2 diabetes,and provided theoretical basis for related research.
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