Simultaneous Determination of Various Sweeteners in Syrup Preparations Based on High Performance Liquid Chromatography
In this study,multiple sweeteners in syrup preparations were determined simultaneously by high performance liquid chromatography(HPLC).The method was also validated for the determination of acesulfame,sodium saccharin,aspartame and neotame in syrup preparations.The results showed that the R2 of the four sweeteners,acesulfame,sodium saccharin,aspartame and neotame,were greater than 0.999 in the range of 0～100.0 μg·mL-1;the detection limits of the four sweeteners were 0.01～0.05 μg·mL-1,and the limits of quantification(LOQ)were 0.03～0.15 μg·mL-1;and the recoveries of the four sweeteners spiked were in the range of 95.6%～02.6%.The method is capable of rapid and simultaneous determination of multiple sweeteners in syrup preparations with accurate and reliable method and high sensitivity.
high performance liquid chromatographysyrup preparationssweetenersdetermination
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