Objective To investigate the surgical outcome and its predictors in patients with cerebral cavernous malformation(CCM)-related epilepsy.Methods Patients with CCM-related epilepsy(CRE)who underwent resective surgery at our epilepsy center from January 2012 to December 2021 were collected,and their demographic and clinical data were retrospectively an-alyzed to identify potential predictors of surgical outcome using univariate analysis and multivari-able logistic regression analysis.Results A total of 71 patients with CRE were included.Postop-erative outcome was graded according to Engel class:78.9％(56/71)as Engel class Ⅰ;21.1％(15/71)as Engel class Ⅱ-Ⅳ,with a mean follow-up of 71.7±35.2 months(12～124 months).Univariate analysis showed that epilepsy duration,distribution of interictal epileptiform discharges and seizure frequency were associated with surgical outcome,whereas the location and number of CCMs were not associated with outcome,and multivariable logistic regression analysis showed that only epilepsy duration was an independent predictor of postoperative outcome(OR=0.928,95％CI 0.861-0.999,P=0.046).Conclusion Patients with CRE have good long-term surgical outcomes with resective surgery,and short epilepsy duration independently predicts good surgical outcomes;therefore,early surgical treatment of patients with CRE is recommended.
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