Objective To investigate the interaction of MRI parameters volume transport con-stant(Ktrans)and rate constant(Ve)with serum interleukin 10(IL-10)and vascular endothelial growth factor(VEGF)in patients with glioma and their diagnostic value in the grading of glioma.Meth-ods A retrospective study was conducted,120 patients with brain glioma who were treated in neurosur-gery of our hospital from October 2020 to October 2022 were selected as the study group,and another 90 patients who underwent craniotomy due to cerebral hemorrhage were selected as the control group.The study group used dynamic contrast-enhanced MRI to obtain the Ktrans value and Ve value,and com-pared the levels of serum IL-10 and VEGF between the two groups.Pearson correlation analysis showed the correlation between Ktrans value and Ve value and serum IL-10 and VEGF levels,respectively.The Ktrans and Ve values,serum IL-10 and VEGF levels of patients with different grades of glioma were analyzed,and the diagnostic value of each index on the grade of glioma was analyzed by ROC curve.Re-sults The levels of serum IL-10(25.97±7.41 pg/ml 比 14.79±3.37 pg/ml)and VEGF(167.01±34.32 pg/ml vs 90.86±13.64 pg/ml)in the study group were significantly higher than those in the control group(P＜0.05).There were 63 patients with high grade and 57 patients with low grade,and the levels of serum IL-10(30.62±6.22 pg/ml vs 20.97±4.93 pg/ml),VEGF(191.05±28.61 pg/ml vs 141.22±16.63 pg/ml),Ktrans(0.333±0.097 min-1 vs 0.234±0.068 min-1)and Ve(0.473±0.136 min-1 vs 0.277±0.091 min-1)in high grade patients were signifi-cantly higher than those in low grade patients(P＜0.05).Pearson correlation analysis showed that the grade of glioma was positively correlated with the levels of IL-10,VEGF,Ktrans and Ve(r=0.538,0.624,0.502,0.541;P＜0.001),and the serum levels of IL-10,VEGF were positive-ly correlated with Ktrans and Ve(r=0.552,0.695,0.550,0.602;P＜0.05).The AUC of serum IL-10,VEGF,KTrans and Ve values in diagnosis of high-grade tumors were 0.804(0.704～0.905),0.808(0.717～0.900),0.793(0.701～0.886),0.815(0.721～0.909),0.882(0.810～0.953),respectively.The AUC of combined diagnosis was higher than that of single diagnosis(P＜0.05).Conclusion The MRI parameters Ktrans and Ve are positively correlated with the serum levels of IL-10 and VEGF in patients with glioma,and have good diagnostic efficacy for the grading of glioma.
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