烟雾病患者血脂代谢特点及其临床意义
Characteristics and clinical significance of serum lipid metabolism in patients with Moyamoya disease
王阿俊 1张楠 2李楠 2杨涛 2李冬雪 2夏成雨1
作者信息
- 1. 230001 合肥 安徽医科大学附属省立医院神经外科
- 2. 中国科学技术大学附属第一医院神经外科
- 折叠
摘要
目的 分析烟雾病患者的血脂代谢特点及血脂水平与其临床特征的关系.方法 收集2015年1月-2023年10月在安徽医科大学附属省立医院就诊的214名烟雾病患者临床特征及血脂检验结果,同时选取214名健康体检者作为对照组.运用SPSS 26.0比较各组间血脂水平及脂代谢异常特点并对其与临床特征的相关性进行分析.结果 烟雾病患者脂代谢异常的患病率为50.9％,主要以高TG血症及低HDL-C血症为主,与对照组相比,烟雾病患者TG水平明显升高(P＜0.05).随着BMI的升高,TG水平越来越高,而HDL-C的水平越来越低(P＜0.05).缺血型患者比出血型患者有较高的TC、TG、LDL-C水平.结论 烟雾病患者存在较高的血脂代谢异常率,主要以高TG血症及低HDL-C血症为主;以脑梗死为首发症状的患者更是如此;在临床工作中要尽早对烟雾病患者进行血脂干预.
Abstract
Objective To analyze the characteristics of blood lipid metabolism in patients with Moyamoya disease(MMD)and the relationship between blood lipid levels and clinical features.Methods The clinical characteristics and blood lipid test results of 214MMD patients in Anhui Provincial Hospital Affiliated to Anhui Medical University from January 2015 to October 2023 were collected,and 214 healthy subjects were selected as the control group.SPSS 26.0 was used to compare the lipid levels and the characteristics of abnormal lipid metabolism in each group,and the correlation between lipid levels and clinical characteristics was analyzed.Results The prevalence of abnormal lipid metabolism in MMD was 50.9％,mainly hypertriglyceridemia and low HDL-C.Compared with the control group,the level of TG in MMD patients was significantly higher(P＜0.05).With the increase of BMI,the level of TG was higher and the level of HDL-C was lower(P＜0.05).The levels of TC,TG and LDL-C in ischemic patients were higher than those in hemorrhagic patients.Conclusion Patients with MMD have a high rate of dyslipidemia,mainly hypertriglyceridemia and low HDL-C,especially in patients with cerebral in-farction as the first symptom.In clinical work,patients with MMD should be intervened as early as possi-ble.
关键词
烟雾病/脂代谢/高脂血症/患病率/干预Key words
Moyamoya disease/Lipid metabolism/Hyperlipidemia/Prevalence rate/Inter-vention引用本文复制引用
基金项目
安徽省重点研发计划(1804h08020250)
出版年
2024
NETL
NSTL
万方数据