Objective To analyze the characteristics of blood lipid metabolism in patients with Moyamoya disease(MMD)and the relationship between blood lipid levels and clinical features.Methods The clinical characteristics and blood lipid test results of 214MMD patients in Anhui Provincial Hospital Affiliated to Anhui Medical University from January 2015 to October 2023 were collected,and 214 healthy subjects were selected as the control group.SPSS 26.0 was used to compare the lipid levels and the characteristics of abnormal lipid metabolism in each group,and the correlation between lipid levels and clinical characteristics was analyzed.Results The prevalence of abnormal lipid metabolism in MMD was 50.9%,mainly hypertriglyceridemia and low HDL-C.Compared with the control group,the level of TG in MMD patients was significantly higher(P<0.05).With the increase of BMI,the level of TG was higher and the level of HDL-C was lower(P<0.05).The levels of TC,TG and LDL-C in ischemic patients were higher than those in hemorrhagic patients.Conclusion Patients with MMD have a high rate of dyslipidemia,mainly hypertriglyceridemia and low HDL-C,especially in patients with cerebral in-farction as the first symptom.In clinical work,patients with MMD should be intervened as early as possi-ble.