Objective Analyze the clinical efficacy of endoscopic assisted subtemporal ap-proach in the treatment of severe brainstem hemorrhage.Methods Retrospective analysis of 78 patients with severe brainstem hemorrhage admitted to our hospital from January 2021 to January 2023,according to the choice of the patients'family members,they were divided into operation group and conservative management.There were 36 cases in the surgical group and 42 cases in the conservative group.The surgical group used endoscope to clear the hematoma through the sub-temporal approach,while the conservative group used symptomatic treatment according to the treatment guidelines for cerebral hemorrhage.Compare the complications,clinical prognosis,and changes in serum NSE and S100B levels between the two groups.Results Compared with the conservative group,the number of patients with severe pneumonia,lower limb venous thrombo-sis,electrolyte disorder and Irritability ulcer in the operation group was less than that in the con-servative group.The difference between the two groups was statistically significant(P<0.05).By comparing the Glasgow prognostic score(GOS)of the two groups,it was found that the num-ber of patients with normal life and mild disability in the operation group was more than that in the Conservative management group,and the number of patients with severe disability was less than that in the Conservative management group.The difference between the two groups was sta-tistically significant(P<0.05).After 1 and 2 weeks of treatment,it was found that the levels of NSE and S100B in the serum of the surgical group were significantly lower than those of the con-servative group,with a statistically significant difference(P<0.05).Conclusion The treatment of severe brainstem hemorrhage through the infratemporal approach assisted by neuroendoscopy can reduce complications and mortality in patients,and improve their prognosis.