Objective To observe the effectiveness and safety of intravenous thrombolysis with rt-PA in patients of acute mild ischemic stroke.Methods Retrospective analyze a total of 107 acute ischemic stroke patients with baseline NIHSS≤3 were enrolled in the study who hospi-talized in Shanghai Jiading District Central Hospital from January 2021 to December 2021.Acco rding to whether performing intravenous thrombolysis or not,107 patients were divided into in-travenous thrombolysis group(n=49)and non-venous thrombolysis group(n=58).The baseline and clinical data were recorded for both groups and their differences were compared.The scores and the rates of reduction of NIHSS in 24 h,7d and 14 d after treatment of the two groups were analyzed,also the scores of 7dmRs and 90dmRS.The incidence of extracranial/intracranial hem-orrhage,the rate of death was also compared between the two groups.Results There were no sig-nificant differences in baseline data and 24 hNIHSS score.NIHSS in 7 d and 14d after treatment were lower in intravenous thrombolysis group,p was 0.020 and 0.008 respectively.The rate of reduction of NIHSS in 24 h,7d and 14 d were higher in intravenous thrombolysis group,all the three p were 0.000.The scores of 7 d and 90dmRS were lower in intravenous thrombolysis group,but only 7dmRS score between the two groups was statistically significant,P=0.014,while 90dmRS score between the two groups was not statistically significant,P=0.153.Both at 7 d and 90 d,the proportions of good prognosis(mRS score 0-2)inintravenous thrombolysis group were higher,but there was no differencebetween the two groups,neither at 7 d nor at 90 d after treat-ment,p were 0.109 and 0.358 respectively.The incidences of extracranial hemorrhage and in-tracranial hemorrhagewere higher in intravenous thrombolysis group,p was 0.000 and 0.018 re-spectively.But no symptomatic intracranial hemorrhageand death occurred in both groups.Conclu-sion Thrombolysis with rt-PA inmildacuteischemicstroke(NIHSS≤3)can improve early neu-rological deficits,increase the incidence of mild extracranial/intracranial hemorrhage,but with no serious adverse outcome.
NETL
NSTL
万方数据
