Influence of preoperative MRI+3D slicer technology-based microscopic resection on tumor markers,neurological function and prognosis in patients with glioma
Objective To observe the clinical application of microscopic resection based on preoperative magnetic resonance imaging(MRI)combined with 3D slicer technology in glioma,and to analyze its influence on tumor markers,neurological function and prognosis.Methods A total of 103 patients with glioma admitted to the hospital were included in the study from July 2018 to February 2023.54 cases were treated with conventional guided surgical resection(the con-trol group),and the remaining 49 cases carried out preoperative MRI+3D slicer-based micro-scopic resection(the study group).The two groups were compared in terms of surgical related in-dicators,tumor markers[neuron-specific enolase(NSE),vascular endothelial growth factor(VEGF),carbohydrate protein 153(CA153)],neurological function,complications and prognosis status.Results Compared with the control group,the intraoperative blood loss in the study group was significantly less(P＜0.05),and the ambulation time was significantly shorter(P＜0.05).The overall total resection rate in the study group(87.76％)was significantly higher than that in the control group(P＜0.05).The levels of NSE,VEGF and CA153 were significantly lower in the study group than those in the control group(P＜0.05).The NIHSS score was different be-tween the two groups at different time points after surgery(P＜0.05).The NIHSS score was lower in the study group compared to the control group(P＜0.05),and the decrease trend of NIHSS score was different between both groups(P＜0.05).No significant difference was shown in the total incidence rate of postoperative complications'between groups(P＞0.05).After 12 months of follow-up,compared with the control group,the study group had significantly lower tumor recurrence rate(P＜0.05),but there was no obvious difference in the survival rate between the two groups(P＞0.05).Conclusion Compared with conventional resection,preoperative MRI+3D slicer technology-based microscopic resection can improve the total resection rate of le-sion,reduce the levels of NSE,VEGF and CA153 and neurological damage,and help to reduce postoperative recurrence.
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