Objective To explore the spatio-temporal characteristics of electroencephalo-gram(EEG)in patients with focal epilepsy and its correlation with drug resistance.Methods A total of 123 patients with focal epileptic seizures who underwent electroencephalogram(EEG)ex-amination in our hospital from January 2020 to July 2022 were selected for this study.According to whether they were resistant to drug,they were divided into a drug-resistant group(45 cases)and a sensitive group(78 cases).The clinical data and electroencephalogram(EEG)spatio-tem-poral characteristics were compared between the drug resistance group and the sensitive group.Multivariate logistic regression was used to analyze the influencing factors of drug resistance in patients with focal seizures.The structural equation prediction model was established and veri-fied.Results The total EEG energy and the level of EEG seizures in the sensitive group were sig-nificantly higher than those in the resistant group(P＜0.001).The proportion of α energy in the sensitive group was significantly lower than that in the drug-resistant group(P=0.015),and the proportion of y energy was significantly higher than that in the drug-resistant group(P＜0.001).The course of disease ≥10 years,seizure frequency≥4 times/month,poor initial treat-ment effect,temporal lobe origin,stroke history,abnormal neurophysiological seizure,and epilep-tic discharge after treatment were independent risk factors for drug resistance in patients with fo-cal epilepsy(P＜0.05).The overall fitness of the structural equation model was better,which could well reflect the relationship between various influencing factors and the occurrence of drug resistance in patients with focal epilepsy.The convergent validity and combined reliability of the model were good.The course of disease≥10 years,seizure frequency≥4 times/month,poor initial treatment effect,temporal lobe origin,stroke history,abnormal neurophysiological seizure,and ep-ileptic discharges after treatment are independent risk factors for drug resistance in patients with focal epilepsy.There are characteristic differences in the power spectrum of EEG between drug-resistant focal epilepsy patients and sensitive focal epilepsy patients.Conclusion The course of disease≥10 years,seizure frequency≥4 times/month,poor initial treatment effect,temporal lobe origin,stroke history,abnormal neurophysiological seizure,and epileptic discharges after treat-ment are independent risk factors for drug resistance in patients with focal epilepsy.There are characteristic differences in the power spectrum of EEG between drug-resistant focal epilepsy patients and sensitive focal epilepsy patients.
Focal epilepsiesTemporal and spatial characteristics of EEGDrug resistant
NETL
NSTL
万方数据
