Objective To investigate the expression changes of long non-coding RNA plasmacytoma variant translocation 1(lncRNA PVT1)in the plasma of patients with intracranial aneurysms and its clinical significance.Methods A total of 30 patients with unruptured intracra-nial aneurysms and 30 patients with ruptured aneurysms were selected from Anqing Traditional Chinese Medicine Hospital between January 2023 and June 2024.An additional 30 healthy individ-uals undergoing routine health check-ups were included as a control group.The expression levels of LncRNA PVT1 in plasma samples from all enrolled subjects were measured using quantitative real-time PCR(qRT-PCR),and the levels of inflammatory factors IL-8 and TNF-α were an-alyzed using ELISA.Clinical data and plasma LncRNA PVT1 levels were compared between the healthy control group and the intracranial aneurysm group.Receiver operating characteristic(ROC)curve analysis was performed to assess the value of plasma LncRNA PVT1 levels in eval-uating intracranial aneurysms and differentiating between unruptured and ruptured aneurysms.The correlation between plasma LncRNA PVT1 levels and inflammatory factors IL-8 and TNF-α was analyzed using Pearson correlation.Results The levels of plasma LncRNA PVT1 in pa-tients with intracranial aneurysms were significantly higher than those in the control group,with the ruptured aneurysm group showing higher levels than the unruptured group.A positive corre-lation was found between plasma LncRNA PVT1 levels and the expression of IL-8 and TNF-α,which was statistically significant(P＜0.05).The ROC curve showed that the AUC for plasma LncRNA PVT1 in predicting intracranial aneurysms was 0.808,with a sensitivity of 80.0％and specificity of 97.8％.The AUC for differentiating between unruptured and ruptured intracranial aneurysms was 0.769,with a sensitivity of 86.7％and specificity of 73.3％.Conclusion The ele-vated expression levels of plasma LncRNA PVT1 in patients with intracranial aneurysms are as-sociated with inflammatory factors and the severity of aneurysms.This suggests that LncRNA PVT1 may play a role in the progression of intracranial aneurysms by regulating the expression levels of inflammatory cytokines.
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