Objective To investigate the changes and significance of resting EEG power spectral density and coherence in patients with migraine(MP).Methods 45 patients with inter-phase migraine without aura diagnosed in the outpatient of Neurology department of the First Af-filiated Hospital of University of Science and Technology of China from January 2022 to June 2022 were included in the migraine group(MP)and 45 healthy subjects in our hospital during the same period were included in the control group(HC).The resting state EEG signals and related clinical indexes were collected.The EEG power spectral density and coherence at different fre-quency bands δ(1-3.9Hz),θ(4-7.9Hz),α(8-12.9Hz)and β(13-29.9Hz)of 19 channels in the two groups were calculated,and the statistical differences of the above indexes were compared between the two groups.Results Power spectrum analysis showed that compared with HC group,EEG power spectrum density of δ band in FP1 and FP2 channels in MP group decreased,and all channels in θ,α and β bands in MP group were decreased,and the differences were statisti-cally significant(correction P＜0.05).Compared with HC group,the average EEG power spectral density of the whole brain in θ,α and β bands except for the 8 band were significantly decreased in MP group,and the differences were statistically significant(correction P＜0.05).Coherence anal-ysis showed that there are a large number of edges with weakened connection on the frontal parie-tal temporal occipitoparietal in θ,α and β bands in MP group,while there are a few weakened ed-ges in δ band.The differences were statistically significant(correction P＜0.05).There is no edge with enhanced connection in δ,θ,α and β bands in MP group.(correction P＞0.05).Conclusion There are abnormalities of EEG power and coherence in migraine patients.It provides new insight for diagnosis and treatment of Migraine in future.
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