Design and Synthesis of PI3Kδ Inhibitor Based on 1H-Pyrazolo[3,4-b]pyridine Structure
Malignant tumours pose a significant threat to human health and life.The Phosphatidylinositol 3-kinase(PI3Ks)family plays a pivotal role in cell proliferation and differentiation.This kinase and other kinases associated with its pathway can be targeted by phar-maceutical interventions,making them a popular target for anti-cancer drugs.Among previous PI3K inhibitors,a common 1H-pyrazolo[3,4-b]pyridine structure was identified.Through virtual screening and synthetic route design,a series of 1H-pyrazolo[3,4-b]pyridine compounds were synthesized,which may potentially inhibit PI3Kδ.
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