首页|谷物膳食纤维通过肠道菌群-胆汁酸途径调控糖脂代谢的研究进展

谷物膳食纤维通过肠道菌群-胆汁酸途径调控糖脂代谢的研究进展

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糖脂代谢紊乱与肥胖、非酒精性脂肪肝、高血脂、糖尿病等慢性代谢疾病的发生发展密切相关。谷物膳食纤维作为一种益生元可降低机体血糖和血脂水平,调控糖脂代谢平衡。目前,关于谷物膳食纤维对糖脂代谢的调节研究主要集中在其理化性质及代谢产物短链脂肪酸等方面。研究发现膳食纤维的摄入可通过调节胆汁酸的代谢平衡调控糖脂代谢稳态,这一过程与肠道菌群密切相关。综述了谷物膳食纤维通过肠道菌群-胆汁酸途径的糖脂代谢调节作用和调控机制研究进展,并举例了不同谷物(糙米、小麦、燕麦和其他谷物等)膳食纤维如何调控糖脂代谢,旨在更好地了解谷物膳食纤维、肠道微生物-胆汁酸和糖脂代谢之间的关系,为深入了解谷物膳食纤维如何改善糖脂代谢、维护人体健康提供新的参考见解。
Research Advances in the Role of Cereal Dietary Fiber in Modulating Glucose and lipid Metabolism via the Gut Microbiota-Bile Acid
Disorders in glucose and lipid metabolism are closely linked to chronic metabolic diseases,including obesity,non-alcoholic fatty liver,hyperlipidemia and diabetes.Cereal dietary fiber,as a prebiotic,can lower blood sugar and lipid levels while promoting metabolic balance.Current research on cereal dietary fiber primarily focuses on its physicochemical properties and short-chain fatty acids metabolites.Recent studies suggest that dietary fiber intake regulates glucose and lipid homeostasis by modulating bile acid metabolism.This process is closely associated with gut microbiota.Therefore,this paper briefly reviewed the progress on the regulatory effects and mechanisms of glucose and lipid metabolism through the gut microbiota-bile acid pathway by grain dietary fiber,and provides examples of how dietary fiber from different grains(brown rice,wheat,oats,and other grains)regulates glucose and lipid metabolism.This review aims to elucidate the relationship between cereal dietary fiber,gut microbiota-bile acid interactions,and glucose and lipid metabolism.It provides new insights into how grain dietary fiber improves metabolic health and supports human well-being.

cereal dietary fibergut microbiotabile acidglucose and lipid metabolism

董洪旺、綦文涛、彭文婷、宋歌、方微

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中南林业科技大学 食品科学与工程学院,稻谷及副产物深加工国家工程研究中心,湖南 长沙 410004

国家粮食和物资储备局科学研究院 粮食品质营养研究所,北京 100037

谷物膳食纤维 肠道菌群 胆汁酸 糖脂代谢

2025

粮油食品科技
国家粮食局科学研究院

粮油食品科技

北大核心
影响因子:0.684
ISSN:1007-7561
年,卷(期):2025.33(1)