Taking the selected gazelle enterprises in Fujian Province as the research object,the study found that the two centers around Gulou District and Xiamen islandshowes a spatial pattern of"North-South nuclear linkage devel-opment and coastal distribution as corridor".Based on the geographical detector model,it is found that the main fac-tors affecting the spatial differentiation of gazelle enterprises are innovation ability and regional innovation environ-ment.In addition,factor agglomeration and location characteristics also affect the spatial distribution of Gazelle enter-prises.Interactive detection analysis shows that spatial differentiation is not caused by a single factor,but by the in-teraction and coupling of multiple factors.Finally,the paper puts forward some policy suggestions from the perspec-tives of building a professional R&-D team,so as to improve the allocation efficiency of human capital factors,and en-hance the quality of patents and promoting the construction of accelerators.