Mechanisms of Drug Resistance Associated with Acinetobacter baumannii and Treatment Progress
Acinetobacter baumannii,a prevalent multidrug-resistant pathogen in Intensive Care Units,poses a significant threat to critically ill patients.With limited effective antibiotic options,Acinetobacter baumannii infections lead to high infection and mortality rates.Its resistance mechanisms include efflux pump activity,target mutations,activation of antibiotic-modifying enzymes,biofilm formation,and quorum sensing system regulation.Recognizing Acinetobacter as a priority for antibiotic development,this article emphasized the urgency of developing new antibiotics.It concentrated on novel antibiotic development,exploring non-traditional antimicrobial agents,potential vaccines,and advancing multimodal infection control strategies,serving as both preventive and alternative therapeutic responses to the escalating challenge of antibiotic resistance.
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