Preparation and characterization of sheepskin collagen-polylactic acid composite nanofiber
In order to study the biocompatibility and degradability of medical materials,sheep skin collagen polylactic acid composite nanofibers were prepared by electrospinning method.The effects of spinning speed,spinning distance,and spinning voltage on the spinning effect were investigated.The prepared nanofibers were subjected to scanning electron microscopy(SEM),Fourier transform infrared(FTIR),X-ray photoelectron spectroscopy(XPS),X-ray diffraction(XRD),thermogravimetry(TG),differential scanning calorimetry(DSC),in vitro degradation,and mechanical properties testing.The results show that when the mass ratio of sheepskin collagen to polylactic acid is 2∶8,the spinning speed is 1.0 mL/h,the spinning distance is 15 cm,and the spinning voltage is 15 kV,the quality of sheepskin collagen polylactic acid composite nanofibers is the best,and sheepskin collagen had a good binding with PLA.The degradation performance of composite nanofibers within 30 days is better than that of pure PLA.When the average cross-sectional area is 0.076 mm2,the tensile strength is 3.549 MPa and the elongation at break is 8.69%.The composite nanofibers prepared from sheep skin collagen polylactic acid have good biodegradability and can be extended to the medical field.
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