Corrosion and in vitro cytocompatibility investigation on the designed Mg-Zn-Ag metallic glasses for biomedical application

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外文摘要：In the present work,seven Mg-Zn-Ag alloys with the nominal composition of Mg96-xZn,Ag4(x=17％,20％,23％,26％,29％,32％,35％in atomic percent)were prepared by induction melting and single-roller melt-spinning.The X-ray diffraction(XRD)analyses indicate the metal-lic glasses with three composition of Mg73Zn23Ag4,Mg70Zn26Ag4,and Mg67Zn29Ag4 were obtained successfully.The differential scanning calo-rimetry(DSC)measurement was used to obtain the characteristic temperature of Mg-Zn-Ag metallic glasses for the glass-forming ability analy-sis.The maximum glass transition temperature(Trg)was found to be 0.525 with a composition close to Mg67Zn29Ag4,which results in the best glass-forming ability.Moreover,the immersion test in simulated body fluid(SBF)demonstrate the relative homogeneous corrosion behavior of the Mg-Zn-Ag metallic glasses.The corrosion rate of Mg-Zn-Ag metallic glasses in SBF solution decreases with the increase of Zn content.The sample Mg67Zn29Ag4 has the lowest corrosion rate of 0.19 mm·a-1,which could meet the clinical application requirement well.The in vitro cell experiments show that the Madin-Darby canine kidney(MDCK)cells cultured in sample Mg67Zn29Ag4 and its extraction medium have higher activity.However,the Mg-Zn-Ag metallic glasses exhibit obvious inhibitory effect on human rhabdomyosarcoma(RD)tumor cells.The present investigations on the glass-forming ability,corrosion behavior,cytocompatibility and tumor inhibition function of the Mg-Zn-Ag based metallic glass could reveal their biomedical application possibility.

外文关键词：

Metallic glassesMg-Zn-AgCorrosion behaviorIn vitro cytocompatibility

作者：

Jian Wang、Lingzhong Meng、Weixin Xie、Chen Jia、Ronghua Wang、Pinghu Zhang、Liling Jin、Liyuan Sheng、Yufeng Zheng

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作者单位：

School of Mechanical Engineering,Yangzhou University,Yangzhou,225127,China

Department of Materials Science and Engineering,Seoul National University,Seoul,South Korea

Huizhou Port Customs,Huizhou,516081,China

Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases,Institute of Translational Medicine,Medical College,Yangzhou University,Yangzhou,225009,China

Center for Research in Computational Thermochemistry(CRCT),Department of Chemical Engineering,Ecole polytechnique de Montréal,Montréal,Québec,H3C 3A7,Canada

Shenzhen Institute,Peking University,Shenzhen 518057,China

PKU-HKUST ShenZhen-HongKong Institution,Shenzhen,518057,China

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基金：

National Key Research and Development Program of ChinaGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationGuangdong Basic and Applied Basic Research FoundationShenzhen Basic Research ProjectShenzhen Basic Research ProjectShenzhen Basic Research ProjectIER FoundationIER Foundation

项目编号：

2018YFC11067022020A15150113012019A15151100672020A1515110055JCYJ20210324120001003JCYJ20200109144608205JCYJ20200109144604020HT-JD-CXY-201902HT-JD-CXY-201907

出版年：

2024

DOI：

10.1016/j.jma.2022.09.025

镁合金学报(英文)

ISSN：2213-9567

年,卷(期)：2024.12(4)