首页|Antibacterial HA-coatings on bioresorbable Mg alloy

Antibacterial HA-coatings on bioresorbable Mg alloy

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In this study,a calcium-phosphate coating was formed on a Mg-Mn-Ce alloy by the plasma electrolytic oxidation(PEO).The antibiotic van-comycin,widely used in the treatment of infections caused by Staphylococcus aureus(S.aureus),was impregnated into the coating.Samples with vancomycin showed high bactericidal activity against S.aureus.The mechanical and electrochemical properties of the formed coatings were studied,as well as in vitro cytotoxicity tests and in vivo tests on mature male rats were performed.According to SEM,EDS,XRD and XPS data,coatings had a developed morphology and contained hydroxyapatite,which indicates high biocompatibility.The analysis of roughness of coat-ings without and with vancomycin did not reveal any differences,confirming the high roughness of the samples.During electrochemical tests,an increase in corrosion resistance by more than two times after the application of PEO coatings was revealed.According to the results of an in vi-vo study,after 28 days of the implantation of samples with calcium phosphate PEO coating and vancomycin,no signs of inflammation were ob-served,while an inflammatory reaction developed in the area of implantation of bare alloy,followed by encapsulation.Antibiotic release tests from the coatings show a sharp decrease in the concentration of the released antibiotic on day 7 and then a gradual decrease until day 28.Throughout the experiment,no significant deviations in the condition and behavior of the animals were observed;clinical tests did not reveal a systemic toxic reaction.

Bioactive coatingsBiocompatibilityMg alloyPlasma electrolytic oxidationHydroxyapatiteVancomycin

K.V.Nadaraia、D.V.Mashtalyar、M.A.Piatkova、A.I.Pleshkova、I.M.Imshinetskiy、M.S.Gerasimenko、E.A.Belov、V.V.Kumeiko、D.N.Kozyrev、K.A.Fomenko、V.V.Mostovaya、B.R.Torpanov、A.R.Biktimirov、I.S.Osmushko、S.L.Sinebryukhov、S.V.Gnedenkov

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Institute of Chemistry FEB RAS,159 Pr,100-Letiya Vladivostoka,Vladivostok 690022,Russia

Institute of Chemistry FEB RAS,159 Pr.100-letiya Vladivostoka,Vladivostok 690022,Russia

Far Eastern Federal University,10 Ajax Bay,Russky Island,Vladivostok 690922,Russia

A.V.Zhirmunsky National Scientific Center of Marine Biology FEB RAS,17 St.Palchevskogo,Vladivostok 690041,Russia

Regional Clinical Dermatovenerological Dispensary,18 V &.Gamarnika,Vladivostok 690033,Russia

NMIC"Treatment and Rehabilitation Center",3 Ivankovskoe highway,Moscow 125367,Russia

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Russian Science FoundationRussian Science Foundation

22-73-1014923-13-00329

2024

10.1016/j.jma.2024.05.006

镁合金学报(英文)

镁合金学报(英文)

EI
ISSN：2213-9567
年,卷(期)：2024.12(5)