首页|Polydopamine-modified metal-organic frameworks nanoparticles enhance the corrosion resistance and bioactivity of polycaprolactone coating on high-purity magnesium

Polydopamine-modified metal-organic frameworks nanoparticles enhance the corrosion resistance and bioactivity of polycaprolactone coating on high-purity magnesium

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Biodegradable magnesium(Mg)and its alloys exhibit excellent biocompatibility and mechanical compatibility,demonstrating tremendous po-tential for applications in orthopedics.However,the rapid degradation rate has limited their clinical application.Polycaprolactone(PCL)is com-monly employed as a polymer coating to impede the rapid degradation of Mg.Unfortunately,its long-term anti-corrosion capability and bioac-tivity are inadequate.To address these issues,polydopamine(PDA)-modified zeolitic imidazolate framework-8(PZIF-8)bioactive nanoparticles are fabricated and incorporated into the PCL coating.The PZIF-8 particles,featuring catechol motifs,can enhance the compactness of the PCL coating,reduce its defects,and possess biomineralization ability,thereby effectively improving its anti-corrosive and bioactive properties.Moreo-ver,the active substances released from the degradation of the PZIF-8 particles such as Zn2+and PDA are beneficial for osteogenesis.The corro-sion tests indicate that the corrosion current density of PCL-treated sample decreases by more than one order of magnitude and the amount of H2 released decreases from(023±0.12)to(0.08±0.08)mL·cm-2 after doping with the PZIF-8.Furthermore,the improved corrosion resistance and released PDA and Zn2+from the coating can promote osteogenic differentiation by up-regulating the expression of alkaline phosphatase ac-tivity,related osteogenic genes,and proteins.In addition,in vivo implantation experiments in rabbit femur defects further offer strong evidence that the doping of PZIF-8 nanoparticles accelerates bone reconstruction of the PCL coating.In summary,this work implies a new strategy to fab-ricate a PCL-based coating on Mg-based implants by introducing the PZIF-8 particles for orthopedic applications.

PolydopamineZIF-8High-purity magnesiumPolycaprolactone coatingAnticorrosionBone regeneration

Qingyun Fu、Shaojie He、Junjie Yang、Ziyu Su、Ping Li、Xincheng Yu、Weihong Jin、Shulan Xu、Zhentao Yu、Dingsheng Zha

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Center of Oral Implantology,Stomatological Hospital,Southern Medical Universiry,Guangzhou,China

Panyu Hospital of Chinese Medicine,Guangzhou 511400,China

Institute of Advanced Wear & Corrosion Resistant and Functional Materials,Jinan University,Guangzhou 510632,China

First Affiliated Hospital of Jinan University,Guangzhou 510630,China

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Guangzhou science and Technology ProjectGuangzhou science and Technology ProjectGuangdong Basic and Applied Basic Research FoundationNational Natural Science Foundation of ChinaNational Natural Science Foundation of ChinaNatural Science Foundation of Guangdong ProvinceShenzhen Key Laboratory of Musculoskeletal Tissue Reconstruction and Function Restoration and Shenzhen People's Hospital

2021A05050300422019040100602020B151512007881401766321010592022A1515010266ZDSYS20200811143752005

2024

10.1016/j.jma.2023.12.014

镁合金学报(英文)

镁合金学报(英文)

EI
ISSN：2213-9567
年,卷(期)：2024.12(5)