As a signal amplification method,plasmon-enhanced fluorescence technology demonstrated significant potential in practical application in the field of environmental-and biological-assay.Therefore,it is imperative to develop a method for the scalable and reproducible synthesis plasmon-enhanced fluorescence carrier,which plays a vital role in the commercialization of the technology.In this study,plasmonic magnetic microbeads were prepared by magnetic loading and polydopamine coating and subsequent noble metal nano island functionalization using polymer microbeads as the template.It is found that the prepared microbeads can be rapidly separated from the solution under an external magnet,and more 70-fold fluorescence enhancement can be obtained for dye CF647.By comparing with polystyrene bead-based suspension microarray,100-fold detection sensitivity can be achieved for biomarker CEA protein.
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