As a transmembrane glycoprotein receptor,the cluster of differentiation 36(CD36)can bind to a variety of ligands to play a variety of physiopathological regulatory functions.Among them,CD36,as a transporter,can mediate the uptake of oxidized low-density lipoprotein(ox-LDL)and long-chain fatty acids,and plays an important role in cellular lipid metabolism.In recent years,increasing studies have found a close link between incremental CD36 expression and its mediated lipid metabolism and the occurrence and development of tumor.By summarizing the latest research progress of CD36,this article introduces the structure and biological functions of CD36,expounds the regulation of CD36 expression and its role in lipid metabolism regulation,and focuses on summarizing the relationship between lipid metabolism regulated by CD36 and tumorigenesis and development.
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