高迁移率族蛋白1在继发性输尿管狭窄中的作用机制与意义
Mechanism and significance of high mobility group protein 1 in secondary ureteral stenosis
程立 1郑杰 1陶凌松 1刘应清1
作者信息
- 1. 华东师范大学附属芜湖医院 泌尿外科,安徽 芜湖 241000
- 折叠
摘要
输尿管狭窄是一种常见的泌尿系统疾病,其多为继发性病变并对患者的生活质量造成严重影响.高迁移率族蛋白1(high mobility group box 1,HMGB1)是一种高度保守和广泛表达的核蛋白,被认为参与细胞增殖、分化等一系列生物学过程.近年有研究发现HMGB1在输尿管狭窄的发生与发展中起到重要作用.本文对HMGB1在继发性输尿管狭窄中的作用机制、相关HMGB1抑制剂对术后输尿管狭窄防治研究的进展作一综述,旨在为治疗继发性输尿管狭窄提供新思路.
Abstract
Ureteral stricture is a common urinary system disorder that significantly affects the quality of life for patients.High mobility group box 1(HMGB1)is a nuclear protein widely distributed in various cells and is involved in processes such as cell proliferation and differentiation.Recent studies have found that HMGB1 plays an important role in the occurrence and development of ureteral stricture.This article provides an overview of the mechanisms of HMGB1 in ureteral stricture caused by stones and related surgical procedures,as well as the progress in research on HMGB1 inhibitors for the prevention and treatment of postoperative ureteral stricture.The aim is to provide new insights and targets for the treatment of ureteral stricture.
关键词
输尿管狭窄/高迁移率族蛋白1/蛋白质/抑制剂Key words
Ureteral stenosis/High mobility group box 1/Protein/Inhibitor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据