Bioinformatics-based analysis of ATP6V0D2 expression and prognostic value in hepatocellular carcinoma
Objective To investigate the expression and prognostic value of ATP6V0D2 in hepatocellular carcin-oma(HCC)were analyzed based on bioinformatics.Methods The expression of ATP6V0D2 in HCC tissues and normal tissues was analyzed using GEPIA and UALCAN databases,and the relationship between the expression and prognosis of patients was compared.Results ATP6V0D2 was highly expressed in HCC compared with normal tis-sues;the survival of patients with high expression of ATP6V0D2 gene was lower than that of patients with low ex-pression of ATP6V0D2 gene;the difference in ATP6V0D2 gene expression in patients with different clinical stages was not statistically significant(P＞0.05);the expression level of ATP6V0D2 was positively correlated with that of alpha-fetoprotein(AFP)(P＜0.05).Conclusions ATP6V0D2 may be a new therapeutic target for HCC and an im-portant indicator for the diagnosis and prognosis of HCC.
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