The correlation between Low expression of LBR and Thyroid Cancer
Objective To investigate the correlation between low expression of LBR gene and thyroid cancer.Me-thods In this study,TCGA data analysis was used to explore the expression of LBR in thyroid cancer,and to find the different expression in different subtypes.The role of LBR gene in the genesis and development of thyroid cancer was investigated by methylation,immunoinfiltration analysis,immunofluorescence and immunohistochemistry.Re-sults LBR was down-regulated in thyroid cancer,and there were differences of expression among all subtypes(P＜0.05).The ROC curve showed that LBR had a good diagnostic effect of thyroid cancer.The methylation analysis revealed that LBR expression was negatively correlated with two methylation sites in the promoter region(all P＜0.05).Immunoinfiltration analysis revealed a positive correlation between LBR expression and infiltration of eosinophils,helper T cells,and central memory T cells(all P＜0.05).Besides,the co-expression and localization of LBR with TP 53 were found,suggesting that the tumor suppressor effect of LBR may be regulated by TP 53 ex-pression.Conclusions Low expression of LBR promotes the occurrence and development of thyroid cancer.
万方数据
维普
