The correlation between carnitine palmitoyl transferase 1 A gene polymorphisms and risk of hepatocellular carcinoma
Objective To explore the correlation between carnitine palmitoyl transferase 1A(CPT1A)gene pol-ymorphism and the risk of liver cancer.Methods Three SNPS,rs80356779,rs3019594 and rs2846194,were geno-typed and statistically analyzed using MassArray platform in a case-control cohort including 350 patients with hepa-tocellular carcinoma(HCC)and 350 healthy controls.Results The minimum allele A of rs80356779 was signifi-cantly associated with an increased risk of HCC(P＜0.05).The genotype frequency distribution of rs80356779 and rs3019594 loci showed statistically significant differences between the two groups(P＜0.05).In addition,rs80356779 increased the risk of HCC by 2.17 and 2.03 times in explicit and additive models,respectively(P＜0.05),while rs3019594 increased the risk of HCC by 1.92 and 1.36 times in implicit and additive models(P＜0.05).Conclusions CPT1A gene polymorphism is correlated with the risk of HCC,suggesting that rs80356779 and rs3019594 muta-tions can be used as potential screening sites for HCC susceptible populations.
Hepatocellular carcinomaCarnitine palmitoyl transferase 1ASingle nucleotide polymorphismCase-control studyAssociation study
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