Advances in Irreversible Protein Kinase Inhibitors
Protein kinases are a highly conserved enzyme systerm by a variety of enzymes,which are primarily responsible for the transfer of ATP γ-phosphate groups to tyrosine,serine,threonine and other amino acids.These amino acids play a role in signal transduction in cells.To date,the majority of listed kinase inhibitors are non-covalent ATP competitive inhibitors.But recently,the development of an irreversible inhibitors is favored by researchers,because of they can combine with cysteine or other nucleophilic amino acids residues to form covalent bonds in the ATP binding pocket.This article is mainly about the research progress in irreversible protein kinase inhibitors,and discussed the efficient development strategies of new covalent inhibitors.
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