By utilizing a broad-spectrum anticancer drug capecitabine CAP as the template,upconversion nanoparticle as the carrier,3,5-dicarboxy-4-methylacrylic ester azobenzene and acrylated gelatin as the bifunctional monomers,N,N′-methylenebisacryl-amide as the cross-linker,and ammonium persulfate as the initiator,a pH/near-infrared dual-responsive nano-intelligent drug carrier named CAP-MIP,was successfully synthe-sized.The synthesis process involved the surface polymerization and the molecular imprint-ing technique,and the experimental results revealed that CAP-MIP exhibited the outstand-ing drug-loading activity,with an adsorption capacity of 7.00 mg/g,and the remarkable adsorption selectivity(CAP selectivity factor α of 2.904).The maximum cumulative re-lease rates of CAP at the media with pH values of 1.2,6.8,and 8.3 were 1.71%,41.84%,and 89.54%,respectively,with the related equilibrium release time of 40 min,180 min,and 420 min.Under the condition of pH 6.8 and NIR irradiation(λ=980 nm),CAP-MIP demonstrated a rapid release,reaching a maximum cumulative release rate of 96.21%with just 180 min.Furthermore,the stability of CAP-MIP was evi-dent,with a drug loss rate of only 8.29%after seven adsorption-desorption cycles.
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