Progress of circRNA in triple-negative breast cancer
Triple-negative breast cancer(TNBC)is the most aggressive subtype of breast cancer,which is characterized by the absence of the estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2.TNBC has the clinical char-acteristics of high invasion and metastasis,poor prognosis,and poor response to conventional chemotherapy or targeted therapy.Stud-ies have shown that abnormal expression of circular RNA(circRNA)in TNBC is related to the clinicopathological features and progno-sis of TNBC patients.circRNA can participate in the proliferation,metastasis and drug resistance of TNBC by regulating transcrip-tion and splicing,acting as microRNA sponges,binding to proteins,and serving as translation templates.Therefore,circRNA have great application prospects in the early diagnosis,clinical treatment and prognostic monitoring of TNBC.In this review,the formation and mechanism of circRNA were described,and the biological functions and clinical significance of circRNA in TNBC were summarized.
万方数据
维普
