摘要
三阴乳腺癌(TNBC)是乳腺癌中恶性程度最高的亚型,其特征为不表达雌激素受体、孕激素受体和人表皮生长因子受体2.TNBC具有易侵袭和转移、预后不良、对常规化疗或靶向治疗效果不佳的临床特点.研究表明,环状RNA(circRNA)在TNBC组织表达异常,并与TNBC患者的临床病理特征和预后相关.circRNA可通过调控转录和剪接、作为微小RNA海绵、与蛋白质结合以及作为翻译模板,参与TNBC肿瘤细胞增殖、转移和耐药过程.因此,circRNA在TNBC的早期诊断、临床治疗和预后监测方面有广泛的应用前景.本文阐述了 circRNA的形成和作用机制,并总结了 circRNA在TNBC中的生物学功能和临床意义.
Abstract
Triple-negative breast cancer(TNBC)is the most aggressive subtype of breast cancer,which is characterized by the absence of the estrogen receptor,progesterone receptor,and human epidermal growth factor receptor 2.TNBC has the clinical char-acteristics of high invasion and metastasis,poor prognosis,and poor response to conventional chemotherapy or targeted therapy.Stud-ies have shown that abnormal expression of circular RNA(circRNA)in TNBC is related to the clinicopathological features and progno-sis of TNBC patients.circRNA can participate in the proliferation,metastasis and drug resistance of TNBC by regulating transcrip-tion and splicing,acting as microRNA sponges,binding to proteins,and serving as translation templates.Therefore,circRNA have great application prospects in the early diagnosis,clinical treatment and prognostic monitoring of TNBC.In this review,the formation and mechanism of circRNA were described,and the biological functions and clinical significance of circRNA in TNBC were summarized.
维普
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