Analysis of value of peripheral blood miR-4465 and miR-609 detection in the diagnosis of sub-clinical disease progression
Aim To evaluate the clinical value of peripheral blood miR-4465 and miR-6089 levels in the diagnosis of sub-clinical diabetes cardiomyopathy(DCM).Methods 266 subjects with type Ⅱ diabetes were selected.According to echocardio-graphy,49 patients were selected as the DCM group,and 49 non-DCM patients were selected as the control group.Single factor and multiple factor logistic regression analysis were used to identify the risk factors affecting the occurrence of DCM.ROC was used to calculate the diagnostic value of miR-4465 and miR-6089 for DCM.Pearson correlation analysis was used to indicate the correlation between indicators.Results The duration of diabetes in DCM group was longer than that in control group,the level of HbA1c was higher than that in control group,and the levels of miR-4465 and miR-6089 in peripheral blood were lower than that in control group(P＜0.05).Multivariate logistic regression analysis showed that the course of diabetes,HbA1c,peripheral blood miR-4465 and miR-6089 were all risk factors for the occurrence of DCM in diabetes(all P＜0.05).Peripheral blood miR-4465 and miR-6089 have good diagnostic value for DCM.Pearson correlation showed that the course of diabetes and HbA1c were significantly correlated with miR-4465 and miR-6089 in peripheral blood(P＜0.05).Conclusion Peripheral blood miR-4465 and miR-6089 are risk factors of diabetes DCM,and have significant correlation with the course of diabetes and HbA1c,which can be used as new biomarkers for the diagnosis of DCM.
miR-4465miR-6089diabetic cardiomyopathydiagnostic value
万方数据
维普
