Relationship between peripheral blood CD4+CD25+Treg cells,TLR4,hCMV-IgM and carotid atherosclerosis in patients with atherosclerotic acute cerebral infarction
Aim To explore the relationship between peripheral blood CD4+CD25+Treg cells,TLR4,human cytomegalovirus(hCMV)-IgM and carotid atherosclerosis in patients with atherosclerotic acute cerebral infarction(As-ACI).Methods Select 89 As-ACI patients(cerebral infarction group)and 43 healthy individuals(control group)for physical examination.According to the ultrasound results of the internal carotid artery,As-ACI patients were divided into normal endometrial group,endome-trial thickening group,plaque group,and stenosis group.Compare the levels of CD4+CD25+Treg cells in peripheral blood,TLR4 ex-pression in mononuclear cells,hCMV-IgM antibody positivity rate,and intima-media thickness(IMT)among different groups.Analyze the risk factors for carotid artery stenosis in As-ACI patients,and examine the correlation between CD4+CD25+Treg cells,TLR4,and IMT,as well as their predictive value for carotid artery stenosis.Results The levels of CD4+CD25+Treg cells and HDLC in the cerebral infarction group were lower than those in the control group,TLR4 expression,hCMV-IgM antibody positivity rate,TC,TG,LDLC,hs-CRP levels,IMT were higher in the cerebral infarction group than in the control group(P＜0.05).The levels of CD4+CD25+Treg cells in the normal endometrial group,endometrial thickening group,plaque group,and stenosis group de-creased sequentially,while the expression of TLR4,the positivity rate of hCMV-IgM antibody and IMT increased sequentially(P＜0.05).The level of CD4+CD25+Treg cells is negatively correlated with IMT,while the expression of TLR4 is positively correlated with IMT(P＜0.05).Hypertension,CD4+CD25+Treg expression,TLR4 expression,and positive hCMV-IgM antibody are risk factors for carotid artery stenosis in As-ACI patients(P＜0.05).The predictive value of combined detection of CD4+CD25+Treg cells and TLR4 expression levels was higher than that of individual detection(P＜0.05).Conclusion The levels of CD4+CD25+Treg cells,TLR4,and hCMV-IgM antibody positivity rate in peripheral blood are related to the progression of carotid atherosclerosis in As-ACI patients.The combination of CD4+CD25+Treg cells and TLR4 in peripheral blood can better predict the pathological process.
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