To explore the mechanism of Antike capsule in treating liver cancer based on network pharma-cology and molecular docking
Aim To explore the mechanism of Antike capsule in the treatment of hepatocellular carcinoma based on network pharmacology and molecular docking.Methods TCMSP,SWISStarget and Uniprot databases were used to search the active com-pounds and compound targets of Antike capsules.The target of liver cancer disease was obtained by using TCGA database.The drug and disease intersection targets were obtained and imported into Cytoscape 3.8.2 software for drug-target-disease visualization net-work diagram.PPI interaction analysis,survival analysis by limit product method,gene GO function analysis and KEGG pathway a-nalysis were performed for intersection targets,and molecular docking was performed for key targets.Results 215 targets of An-tike capsule and 674 targets of liver cancer were obtained,including 10 intersection targets.The expressions of CYP2C19,GCGR,ADCY1 and DPP4 were negatively correlated with the mortality of liver cancer.The expressions of AURKA,NUDT1,CDK1,AURKB and G6PD were positively correlated with the mortality of liver cancer.Enrichment analysis found that 10 key targets were associated with 19 biological processes,8 cell compositions,6 organizational functions,and 2 signaling pathways.Molecular docking showed that G6PD was the most active target,followed by AURKA.PARP1 was the best binding energy target,followed by AURKA.Conclusion Antike capsule may have effects on CYP2C19,GCGR,ADCY1,AURKA,PARP1,NUDT1,CDK1,AURKB,DPP4,G6PD and other multi-channel treatment for liver cancer,which provides a foundation for further study of its pharma-cological mechanism.
万方数据
维普
