Relationship between c-Met mRNA and NF-κB mRNA expression and its impact on prognosis in patients with cervical cancer
Aim To analyze the relationship between the mRNA of human proto-oncogene c-Met and nuclear transcription factor kappa B(NF-κB)in the pathogenesis of cervical cancer and the effect on prognosis of cervical cancer patients.Methods 89 patients with cervical cancer were selected as the cancer group.89 patients with precancerous cervical lesions were selected as the precancerous group,and 89 patients who underwent total hysterectomy due to uterine fibroids were selected as the normal cervix group.The relative expression of c-Met and NF-κB mRNA in cervical tissues of the three groups was detected by RT-PCR.Spearman/Pearson was used to analyze the relationship between these two in the development of cervical cancer.Kaplan-Meier curves were used to analyze the 3-year survival rates of patients with different c-Met and NF-κB mRNA expression levels.Results The relative ex-pression of c-Met and NF-κB mRNA in cervical tissue was cancer group>precancerous group>the normal cervical group(P<0.05).The c-Met mRNA and NF-κB mRNA in the precancerous group and cancerous group were positively correlated(P<0.05).The high expression of c-Met mRNA and NF-κB mRNA showed a positive interaction in the pathogenesis of cervical cancer(P<0.05).The high expression of c-Met and NF-κB mRNA was positively correlated with the clinical stage,lymph node metastasis,and vascular inva-sion of cervical cancer,and negatively correlated with the degree of differentiation(P<0.05).The 3-year survival rate of patients with high expression of c-Met and NF-κB mRNA in the cancer group was lower than that of patients with low expression(P<0.05).Conclusion The high expression of c-Met mRNA and NF-κB mRNA has a positive interactive effect in the pathogenesis of cervical cancer,and is significantly correlated with clinical stage,lymph node metastasis,and vascular invasion.It also significantly reduces the 3-year survival rate of cervical cancer patients.
万方数据
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