Predictive value of SII combined with CAR in small cell lung cancer prognosis
Aim To analyze the prognostic value of systemic immune inflammation index(SII)combined with C-reactive protein/albumin ratio(CAR)in small cell lung cancer(SCLC).Methods 256 patients with SCLC in our hospital were retro-spectively analyzed.They were divided into 218 cases in the death group and 38 cases in the survival group according to the last fol-low-up.Clinical data of patients in both groups at the time of admission were collected,independent risk factors for all-cause mortali-ty in SCLC patients were analyzed by multifactorial Cox regression analysis,survival curve was drawn by the Kaplan Meier method,and the clinical efficacy of SII combined with CAR for predicting SCLC mortality was assessed by ROC curve.Results The differences in erythrocyte distribution width,neutrophil/lymphocyte ratio(NLR),SII,CAR,D-dimer,and TNM staging between the survival group and the death group were all significant(P<0.05).The 3-year survival rates of the low SII group and low CAR group were higher than those of the high SII group and high CAR group,respectively(P<0.05).The results of multifactorial Cox regression analysis showed that NLR>3.5,SII>766×109/L,CAR>0.52,and TNM stage Ⅳ were the independent risk factors for all-cause mor-tality in SCLC patients.ROC curve showed that the AUC of SII combined with CAR to predict all-cause mortality in SCLC patients was higher than that of NLR combined with CAR,and therefore had the best predictive performance.Conclusion SII combination CAR has better predictive ability for prognosis in SCLC patients.
万方数据
维普
