Effect of Guhong injection combined with nicergoline in the treatment of acute cerebral in-farction and its influence on neurological function recovery and vascular endothelial function
Aim To explore the effect of Guhong injection combined with nicergoline in the treatment of acute cerebral in-farction and the influence on neurologicalfunction recovery and vascular endothelial function.Methods 128 patients with acute cerebral infarction who received treatment were included and randomly divided into observation group(n=64)and control group(n= 64),patients in both groups were given conventional treatment,and the control group was treated with nicergoline,and the observation group was given Guhong injection combined with nicergoline.After 2 weeks of treatment,the clinical efficacy of the two groups was evaluated.Neurological function recovery[National Institutes of Health Stroke Scale(NIHSS),Barthel Index(BI)],vascular en-dothelial function[vascular endothelial growth factor(VEGF),thromboxane-A2(TX-A2),endothelin-1(ET-1),nitric oxide(NO)]and hemorheology(hematokrit,plasma viscosity,platelet aggregation rate,fibrinogen)were compared between the two groups before treatment and after 2 weeks of treatment,and the adverse reactions during treatment were counted.Results After 2 weeks of treatment,the total effective rate in observation group was higher than that in control group(P<0.05).The NIHSS score,vascu-lar endothelial factors(VEGF,ET-1,NO,TX-A2)and hemorheology(hematocrit,plasma viscosity,platelet aggregation rate,fibrin-ogen)in both groups were decreased compared with those before treatment,and the above indicators in observation group were lower compared with those in control group(all P<0.05).BI score was enhanced compared to before treatment,and the score in observa-tion group was higher than that in control group(P<0.05).There is no significant difference in adverse reactions between the two groups(P>0.05).Conclusion Guhong injection combined with nicergoline has a significant effect in the treatment of acute cer-ebral infarction,and it can promote the recovery ofneurologicalfunction,enhance the vascular endothelial function and improve the he-morheological status,and it does not increase the risk of adverse reactions.
acute cerebral infarctionguhong injectionnicergolineneurologicalfunctionvascular endothelial function
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