Effect of trans sulcus fissure approach on cerebral blood flow,neurological function and mi-croinflammation in patients with hypertensive intracerebral hemorrhage in basal ganglia
Aim To investigate the effect of trans sulcus fissure approach on cerebral blood flow,neurological function and microinflammation in patients with hypertensive intracerebral hemorrhage in basal ganglia region.Methods 96 patients with hy-pertensive intracerebral hemorrhage in basal ganglia region were selected and divided into observation group(n=47,via sulcus space approach)and control group(n=49,conventional via gyrocortical surgery)according to different operation methods.Cerebral hemo-dynamics(vascular resistance(Rv),quality manage(Qm),mean velocity(Vm)),neurological deficit score(NHISS),serum nerve factors(nerve growth factor(NGF),neuron specific enolase(NSE),neuropeptide(NPY)),inflammatory factors(high-sensi-tivity C-reactive protein(hs-CRP),matrix metalloproteinase-9(MMP-9),tumor necrosis factor-α(TNF-α))were compared between the two groups.Results The postoperative blood loss,consciousness recovery time and hospitalization time of the observation group were lower than those of the control group(P<0.05).After operation,Rv decreased,whereas Qm and Vm increased.The levels of serum NSE,NGF,NPY,MMP-9,hs-CRP,TNF-α,and NHISS scores decreased in both groups,and the decrease was more significant in the observation group than in the control group(P<0.05).The incidence of complications of tracheotomy and cerebral rebleeding in the observation group was lower than that in the control group(P<0.05).Conclusion The operation by the sulcus fissure approach can effectively improve the clinical efficacy and cerebral blood flow of patients with hypertensive intracerebral hemor-rhage in the basal ganglia,reduce the micro inflammatory state,and promote the recovery of neural function.
trans sulcal fissure approachhypertensive intracerebral hemorrhage in basal ganglia regioncerebral hemody-namicsneurological functionmicroinflammation
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