中南医学科学杂志2024,Vol.52Issue(2) :251-253,264.DOI:10.15972/j.cnki.43-1509/r.2024.02.023

甘油三酯-葡萄糖指数对2型糖尿病患者发生NAFLD的预测价值

Predictive value of triglyceride glucose index for NAFLD in patients with type 2 diabetes mellitus

赵永晓 王艳丽 苏江华 王哲 刘娜
中南医学科学杂志2024,Vol.52Issue(2) :251-253,264.DOI:10.15972/j.cnki.43-1509/r.2024.02.023

甘油三酯-葡萄糖指数对2型糖尿病患者发生NAFLD的预测价值

Predictive value of triglyceride glucose index for NAFLD in patients with type 2 diabetes mellitus

赵永晓 1王艳丽 1苏江华 2王哲 3刘娜1
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作者信息

  • 1. 石家庄市第二医院 消化内科,河北石家庄 050051
  • 2. 石家庄市第二医院 院办公室,河北石家庄 050051
  • 3. 石家庄市第二医院 检验科,河北石家庄 050051
  • 折叠

摘要

目的 探究甘油三酯-葡萄糖指数(TyG)对2 型糖尿病(T2DM)患者发生非酒精性脂肪肝(NAFLD)的预测价值.方法 选取T2DM患者306 例,根据患者TyG四分位数分为Q1 组(n=78)、Q2 组(n=55)、Q3 组(n=89)和Q4 组(n=84),比较患者一般资料和生化指标.随访2 年后进行肝脏彩超检查,比较各组NAFLD发生情况,分析T2DM患者发生NAFLD的危险因素,以及TyG对发生NAFLD的预测价值.结果 由Q1 组至Q4 组,患者血清高密度脂蛋白胆固醇逐渐降低,血压、空腹血糖、谷草转氨酶、谷丙转氨酶、谷氨酰转肽酶、尿酸、低密度脂蛋白胆固醇、总胆固醇、甘油三酯、糖化血红蛋白、TyG 和NAFLD发生率逐渐升高(P<0.05).Logistic回归分析显示,TyG越高NAFLD发病风险越高(P<0.05).TyG对T2DM患者发生NAFLD具有良好的预测价值(P<0.05).结论 TyG可有效预测T2DM患者发生NAFLD,适宜在临床推广应用.

Abstract

Aim To explore the predictive value of triglyceride glucose index(TyG)on nonalcoholic fatty liver disease(NAFLD)in patients with type 2 diabetes mellitus(T2DM).Methods 306 patients with T2DM were selected and divided into Q1 group(n=78),Q2 group(n=55),Q3 group(n=89)and Q4 group(n=84)according to the TyG quartile.The general data and biochemical indexes of patients were compared.After 2 years of follow-up,liver color doppler ultrasound was performed compare the incidence of NAFLD among different groups,analyze the risk factors for NAFLD in T2DM patients,and evaluate the predictive val-ue of TyG for NAFLD occurrence.Results From group Q1 to group Q4,the patients'serum high density lipoprotein cholesterol gradually decreased,and the incidence of blood pressure,fasting blood glucose,glutamic-oxaloacetic transaminase,glutamic-pyruvic transaminase,γ-glutamyl transpeptidase,uric acid,low density lipoprotein cholesterol,total cholesterol,triglycerides,glycosylated hemoglobin,TyG and NAFLD gradually increased(P<0.05).Logistic regression analysis showed that the higher TyG was associated with the higher the risk of NAFLD(P<0.05).TyG has a good predictive value for NAFLD in T2DM patients(P<0.05).Con-clusion TyG can effectively predict the occurrence of NAFLD in T2DM patients,which is suitable for clinical application.

关键词

甘油三酯-葡萄糖指数/2型糖尿病/非酒精性脂肪肝/预测

Key words

triglyceride-glucose index/type 2 diabetes mellitus/non-alcoholic fatty liver disease/prediction

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基金项目

河北省医学科学研究重点课题(20201349)

出版年

2024
中南医学科学杂志
南华大学

中南医学科学杂志

CSTPCD
影响因子:0.757
ISSN:2095-1116
参考文献量13
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