Effects of remimazolam toluenesulfonate combined with low-dose propofol anesthesia induction on stress response in elderly patients with LC
Aim To Explore the effect of remimazolam toluenesulfonate combined with low-dose propofol anesthesia induction on stress response in elderly patients undergoing laparoscopic cholecystectomy(LC).Methods 103 elderly patients undergoing LC were selected and randomly divided into a control group(51 cases,conventional dose propofol)and an observation group(52 cases,remimazolam toluenesulfonate+low-dose propofol).Comparison of anesthesia effects and blood gas indicators at dif-ferent time points between two groups(pH,arterial CO2 partial pressure(PaCO2),arterial oxygen partial pressure(PaO2)),stress levels(plasma cortisol(PC),tumor necrosis factor-α(TNF-α),C-reactive protein(CRP)and occurrence of adverse events).Results The induction onset time of the observation group was slower than that of the control group(P<0.05).There was no signif-icant difference in wake-up time and departure time between the two groups(P>0.05).At the end of the surgery,PC,TNF-α,and CRP level in the observation group was lower than that of the control group(P<0.05).The incidence of hypotension,bradycardia,hypoxemia,and injection pain in the observation group was significantly lower than that in the control group(P<0.05).Conclu-sion The combination of remazolam toluenesulfonate and low-dose propofol has a good anesthetic effect on elderly LC patients,which can effectively stabilize their blood gas indicators,inhibit stress reactions,and is safer than propofol alone.
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