Change and clinical significance of serum PCT,NSE and bispectral index in patients with sepsis-related encephalopathy
Aim To explore the changes of serum procalcitonin(PCT),neuron-specific enolase(NSE),and bispectral in-dex(BIS)in patients with sepsis-related encephalopathy(SAE)and its clinical significance.Methods 98 patients with sepsis were selected and divided into SAE group(n=42)and non-SAE group(n=56)according to the ICU delirium assessment scale.The serum levels of PCT,NSE,and BIS between two groups of patients were compared,the correlation between PCT,NSE,and BIS with Glasgow coma score(Glasgow)was analyzed,and their diagnostic efficacy in predicting SAE was evaluated.Furthermore,the risk factors that affect the occurrence of SAE was analyzed.Results The levels of PCT and NSE in the SAE group were higher than those in the non-SAE group,while the BIS and Glasgow score were lower than that in the non-SAE group(P<0.05).The serum levels of PCT and NSE in patients were negatively correlated with Glasgow score(P<0.001),while BIS was positively correlated with Glasgow score(P<0.001).Serum PCT,NSE,and BIS are independent risk factors for the occurrence of SAE,and PCT,NSE,and BIS have good predictive power for SAE.Conclusion Serum CT,NSE,and BIS in sepsis patients are independent risk factors for the occurrence of SAE and have important value in predicting the occurrence of SAE.
sepsis-related encephalopathyprocalcitoninneuron specific enolasebispectral index
万方数据
维普
