The role of protein nitration modification in the development and progression of heart failure
Nitrative stress is a biochemical reaction that occurs in combination with reactive oxygen species(ROS)and nitric oxide or with active nitrogen species(RNS)derived from nitric oxide.Under stress,the body produces a high concentration of super-oxide anion(O2-)and nitric oxide,and the reaction of the two can produce peroxynitrite,which makes the protein tyrosine residue un-dergo nitration modification to produce 3-nitrotyrosine(3-NT).Therefore,3-NT is usually used to reflect the level of protein nitration modification.The accumulated 3-NT leads to DNA damage,cell death,cardiac structure damage,and cardiac dysfunction.Heart failure,a clinical syndrome that arises in the terminal stages of cardiovascular disease,is one of the important public health problems worldwide.The causes of heart failure are diverse,and it is characterized by high morbidity and poor prognosis.During the patho-logical process of heart failure,nitrative stress levels are markedly elevated in the heart,with a large number of proteins undergoing ni-tration modification and a concomitant increase in 3-NT production.This review focuses on the role of protein nitration modification in the development and progression of heart failure.
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