首页|TRPV4在乳腺癌发生发展中作用的研究进展

TRPV4在乳腺癌发生发展中作用的研究进展

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瞬时受体电位香草素亚型4(TRPV4)是一种非选择性、渗透性阳离子通道,可被各种物理和化学刺激激活从而参与肿瘤的发生发展。TRPV4 在乳腺癌的多个生物学过程中起着关键作用,有望成为乳腺癌诊断和治疗的潜在靶点。现将TR-PV4 在乳腺癌细胞侵袭转移、血管新生及癌细胞死亡等过程中的作用进行综述,以期为乳腺癌的治疗寻找潜在靶点。
Research progression of role of TRPV4 in the occurrence and development of breast cancer
Transient receptor potential vanilloid 4(TRPV4)is a non-selective and permeable cation channel,which can be ac-tivated by various physical and chemical stimuli and participate in the development of tumor.TRPV4 plays a key role in multiple bio-logical processes of breast cancer and is expected to be a potential target for breast cancer diagnosis and treatment.This article re-views the role of TRPV4 in the invasion and migration of breast cancer cells,angiogenesis and cancer cell death in order to find poten-tial targets for the treatment of breast cancer.

TRPV4breast cancerangiogenesisinvasion and migrationcell death

谢珣、张圆、聂晨晨、赵洁、陈志鸿、李艳春

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湖南师范大学附属第一医院 湖南省人民医院,湖南长沙 410000

TRPV4 乳腺癌 血管新生 侵袭转移 细胞死亡

湖南省人民医院仁术基金

RS201902

2024

中南医学科学杂志
南华大学

中南医学科学杂志

CSTPCD
影响因子:0.757
ISSN:2095-1116
年,卷(期):2024.52(2)
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