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原发性肝癌血清标志物:机会与挑战

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原发性肝癌目前的常规筛查方法是甲胎蛋白结合腹部超声,但其灵敏度与特异度严重不足,难以满足原发性肝癌早期诊断的需求。本文总结了原发性肝癌的传统标志物以及新兴血清标志物,重点介绍了在原发性肝癌筛查与早期诊断中富有前景的新型原发性肝癌血清标志物——醛酮还原酶1B10,以期为原发性肝癌的早期诊断带来新思路。
Serum markers for primary liver cancer:opportunities and challenges
The current conventional screening method for primary liver cancer is alpha-fetoprotein combined with abdominal ul-trasound,but its sensitivity and specificity are severely insufficient to meet the needs of early diagnosis of primary liver cancer.This article summarizes the traditional markers and emerging serum markers of hepatocellular carcinoma,and focus on aldo-keto reductase 1 B10,a novel serum marker of primary liver cancer with great potential for early diagnosis,a promising serum marker for hepatocellular carcinoma,in order to bring new ideas for early diagnosis of primary liver cancer.

AKR1B10primary liver cancerserum markersliquid biopsyprotein markers

任晨然、郭敏、王涛、夏机良、曾希、曹德良

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南华大学衡阳医学院肿瘤研究所 肝癌早诊早治湖南省工程研究中心,湖南衡阳 421001

AKR1B10 原发性肝癌 血清标志物 液体活检 蛋白标志物

国家自然科学基金湖南省长株潭国家自主创新示范区专项湖南省普通高等学校科技创新团队支持项目

817728422018XK2106湘教通2023233号

2024

中南医学科学杂志
南华大学

中南医学科学杂志

CSTPCD
影响因子:0.757
ISSN:2095-1116
年,卷(期):2024.52(3)