Predictive value of serum Chemerin and Irisin expression on visual disability in patients with diabetes retinopathy
Aim To study the predictive value of serum Chemerin and Irisin expression on visual disability in patients with diabetic retinopathy(DR).Methods A total of 110 patients with DR(DR Group)were selected and divided into non-visual disability group and visual disability group according to vision differences.Another 110 patients with simple diabetes were selected as control group.Serum Chemerin levels were determined by double antibody sandwich ELISA and serum Irisin levels were determined by ELISA.The risk factors for visual,and the predictive value of serum levels of Chemerin and Irisin expression for visual impair-ment in DR patients was analyzed.Results The serum levels of Chemerin in the DR group were higher than those in the control group,while Irisin was lower than those in the control group.The serum levels of Chemerin in patients with visual impairment were higher than those in the non-visual disability group,while Irisin was lower than those in the non-visual disability group(P＜0.001).The course of diabetes in the visual disability group was longer than that in the non-visual disability group,and their fasting plasma glu-cose(FBG),glycated hemoglobin(HbA1c),homeostatic model assessment of insulin resistance indexes were higher than those in the non-visual disability group(P＜0.05).The course of diabetes in DR patients,the increase of HbA1c and Chemerin,and the de-crease of Irisin were all independent risk factors for visual disability in DR patients(P＜0.05).The combined detection of serum Chemerin and Irisin expression has the highest predictive value for visual disability in patients with diabetes retinopathy(P＜0.05).Conclusion The expression levels of serum Chemerin and Irisin have some predictive values for visual disability in patients with dia-betes retinopathy.
万方数据
维普
