Evaluation value of quantitative parameters of contrast-enhanced ultrasound combined with peripheral blood mononuclear cell miR-34a and miR-146a in the diagnosis and lymph node metastasis of PTC
Evaluation value of quantitative parameters of contrast-enhanced ultrasound combined with peripheral blood mononuclear cell miR-34a and miR-146a in the diagnosis and lymph node metastasis of PTC
Aim To explore the diagnostic and lymph node metastasis evaluation value of contrast-enhanced ultrasound quantitative parameters combined with peripheral blood mononuclear cell(PBMC)miR-34a and miR-146a in papillary thyroid cancer(PTC).Methods 104 patients with PTC in our hospital were selected and divided into a thyroid cancer group of 69 cases and a benign group of 35 cases based on surgical pathological diagnosis.Based on whether or not lymph nodes have metastasized,69 thy-roid cancer patients were divided into a non-metastatic group of 33 cases and a metastatic group of 36 cases.The peak intensity(PI),time to peak(TTP),mean transit time(MTT),area under curve(AUC),and levels of miR-34a and miR-146a in PBMC in different groups were compared.The evaluation value of contrast-enhanced ultrasound parameters combined with PBMC miR-34a and miR-146a in the diagnosis and lymph node metastasis of PTC was analyzed by using ROC curves.Results Compared with the be-nign group,the quantitative parameters and PBMC miR-34a levels in the thyroid cancer group were decreased(P＜0.05),while miR-146a levels were increased(P＜0.05).Compared with the non-metastatic group,the levels of PI,AUC,and miR-146a in the lymph node metastasis group were increased(P＜0.05),while the levels of TTP,MTT,and miR-34a were decreased(P＜0.05).The AUC of quantitative parameters of contrast-enhanced ultrasound and PBMC miR-34a and miR-146a for the diagnosis of thyroid cancer and lymph node metastasis was higher than the individual detection values of various indicators(P＜0.05).Conclusion The combination of quantitative parameters of contrast-enhanced ultrasound and detection of miR-34a and miR-146a indicators in PBMC can enhance the early diagnosis and evaluation of lymph node metastasis in PTC.
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