The effects of different doses of dexmedetomidine on postoperative cognitive function in pa-tients with aneurysmal subarachnoid hemorrhage
Aim To observe the effects of different doses of dexmedetomidine on postoperative cognitive function in patients with aneurysmal subarachnoid hemorrhage.Methods 90 patients with aneurysmal subarachnoid hemorrhage treated were divided into a control group(physiological saline combined with remifentanil),a low-dose group(low-dose dexmedetomidine combined with remifentanil),and a high-dose group(high-dose dexmedetomidine combined with remifentanil),according to different treatment meth-ods,with 30 cases in each group.ELISA was used to detect the levels of serum neurological function index S100β,neuron specific enolase(NSE),vascular endothelial function index endothelin-1(ET-1),and monocyte chemotactic protein-1(MCP-1)in each group before and one day after surgery.The mini-mental state examination(MMSE)was used to evaluate the cognitive function of patients before and 3 days after surgery.The incidence of adverse reactions during surgery and the incidence of postoperative cognitive dysfunction(POCD)in each group were compared.Results Three days after surgery,the MMSE scores in each group were de-creased compared with those before surgery(P＜0.05),and in an order of high-dose group＞low-dose group＞control group(P＜0.05).The incidence of POCD in both high-dose and low-dose groups was lower than that in the control group(P＜0.05).On the first day af-ter surgery,S100β and NSE in each group were increased compared with them before surgery(P＜0.05),while ET-1 and MCP-1 were decreased compared with them before surgery(P＜0.05),and in an order of high-dose group＜the low-dose group＜the control group(P＜0.05).There was no statistically significant difference in the incidence of adverse reactions among the three groups(P＞0.05).Conclusion Dexmedetomidine can improve postoperative cognitive function and reduce the incidence of cognitive dysfunction in patients with aneurysmal subarachnoid hemorrhage.Infusing dexmedetomidine at a dose of 0.5 g/(kg·h)has a better effect.
万方数据
维普
