Plantar pressure changes in diabetic peripheral neuropathy and its relationship with nerve conduction,sensory current thresholds and inflammatory factors
Aim To investigate the plantar pressure changes in diabetic peripheral neuropathy(DPN)and its relationship with nerve conduction,sensory current thresholds and inflammatory factors.Methods 590 cases with type 2 diabetes mellitus complicated with DPN were included and divided into a control group(no diabetic foot,n=320)and an observation group(diabetic foot,n=270)according to whether they had a diabetic foot or not.Another healthy population with physical examination at the same time was included as a blank group(n=150).Fasting blood glucose(FBG),2 h postprandial blood glucose(2 hPG),glycated he-moglobin(HbA1c),blood fat,peak pressures in different areas of the plantar foot,motor/sensory nerve conduction velocity(NCV),current sensory threshold(CPT),and levels of inflammatory factors[(interleukin-1 β(IL-1β),IL-10,tumor necrosis factor-α(TNF-α)and macrophage inflammatory protein-1α(MIP-1α)]were compared in each group.The correlation of plantar pressure changes with nerve conduction,sensory current thresholds,and inflammatory factors was analyzed.Results Peak plantar pressure,FBG,2 hPG,IL-1β,IL-10,TNF-α,MIP-1α,HbA1c and CPT levels in different regions of the plantar foot in the blank,control,and ob-servation groups were sequentially increased,and NCV was sequentially decreased(P＜0.05).Pearson correlation analysis showed that IL-1β,IL-10,NCV,CPT,TNF-α and MIP-1α were positively correlated with plantar pressure in different areas of the plantar foot(P＜0.05).Conclusion Elevated peak plantar pressures in patients with DPN are closely related with nerve conduction,sensory current thresholds,and inflammatory factors,and may provide a clinical reference.
万方数据
维普
