摘要
目的 探究盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者血清免疫和炎症指标的影响.方法 选取ⅢB型慢性前列腺炎患者120例,随机均分为对照组(盐酸坦索罗辛+前列倍喜)及三联组(盐酸坦索罗辛+前列倍喜+针灸).比较两组临床疗效、治疗前后中医证候评分、美国国立卫生研究院慢性前列腺炎症指数(NIH-CPSI)评分、血清免疫指标[免疫球蛋白(Ig)A、IgM、IgG]和炎症指标[肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-2、IL-8、IL-10]水平.结果 治疗后,三联组治疗总有效率高于对照组(P＜0.05).与治疗前比较,治疗后两组中医证候评分、NIH-CPSI评分、TNF-α、IL-2及IL-8降低,IgA、IgM、IgG升高,且三联组较对照组更为显著(P＜0.05).与治疗前比较,治疗后两组IL-10升高(P＜0.05),但两组间比较差异无显著性(P＞0.05).结论 盐酸坦索罗辛、前列倍喜、针灸三联疗法对ⅢB型慢性前列腺炎患者临床疗效显著,可明显改善其血清免疫和炎症指标.
Abstract
Aim To investigate the effects of triple-therapy of tamsulosin hydrochloride,qianlie beixi and acupuncture on serum immune and inflammatory indexes in patients with type Ⅲ B chronic prostatitis.Methods One hundred and twenty patients with type Ⅲ B chronic prostatitis were selected and randomly divided into the control group(tamsulosin hydrochloride+qian-lie beixi)and the triple-therapy group(tamsulosin hydrochloride+qianlie beixi+acupuncture).The two groups were compared in terms of clinical efficacy,TCM syndrome scores,the national institute of health-chronic prostatitis symptom index(NIH-CPSI)score,and the levels of serum immune indexes(immunoglobulin(Ig)A,IgM and IgG)and inflammatory indexes(tumor necrosis factor-α(TNF-α),interleukin-2,IL-8 and IL-10).Results After treatment,total effective rate in the triple therapy group was higher than that in the control group(P＜0.05).After treatment,there were decreases in TCM syndrome scores,NIH-CPSI scores,TNF-α,IL-2 and IL-8,and increases in IgA,IgM and IgG in both groups,and these effects were more obvious in the triple therapy group in comparison with control group(P＜0.05).After treatment,there were increases in IL-10 levels in both groups(P＜0.05),but there was no significant difference between the groups(P＞0.05).Conclusion The triple-therapy of tamsulosin hydrochloride,qianlie beixi and acupuncture is effective to treat patients with type Ⅲ B chronic prostatitis,which can significantly improve serum immune and inflammatory indexes.
基金项目
上海市虹口区卫生健康委中医药科课题(HKQGYQY-ZYY-2022-19)
维普
万方数据