The correlation between serum 25-(OH)D,ferritin levels and thyroid function in early pregnancy
Aim To determine the correlation between serum levels of 25 hydroxyvitamin D[25-(OH)D]and ferritin(SF)in early pregnancy and thyroid function.Methods 161 early pregnancy women who underwent routine prenatal examinations were selected as the study subjects,and were divided into deficiency group,deficiency group,and adequacy group according to the 25-(OH)D level,or divided into iron deficiency group and iron normal group according to SF level.The levels of thyroid function indi-cators,including serum thyroid stimulating hormone(TSH),free thyroxine(FT4),and thyroid peroxidase antibody(TPO Ab),were compared in different groups of,and the correlation between 25-(OH)D,SF levels and thyroid function indicators was analyzed.Results The serum TPO Ab levels in the 25-(OH)D sufficient group were lower than those in the insufficient and deficient groups,while the insufficient group was lower than the deficient group(P＜0.05).The serum TSH level in the iron normal group was lower than that in the iron deficiency group,and the FT4 level was higher than that in the iron deficiency group(P＜0.05).Pearson corre-lation analysis showed that serum 25-(OH)D levels were negatively correlated with TPO Ab(r=-0.524,P=0.024).The SF level is negatively correlated with TSH level(r=-0.613,P=0.025),but positively correlated with FT4 level(r=0.762,P=0.012).Conclusions The serum TPO Ab levels in early pregnancy are associated with vitamin D deficiency,TSH and FT4 are associated with iron deficiency,and thyroid function indicators are helpful in evaluating vitamin D and iron storage in pregnant women,which is of great clinical significance.
early pregnancythyroid function25-(OH)Dserum ferritincorrelation
万方数据
维普
