Expression levels of serum CHI3L1 and HSP60 in patients with chronic glomerulonephritis and their clinical significance
Aim To explore the expression levels and clinical significance of chitosanase 3-like protein 1(CHI3L1)and heat shock protein 60(HSP60)in patients with chronic glomerulonephritis(CGN).Methods A total of 97 CGN patients were selected as CGN group,whereas 120 healthy subjects were selected as healthy group.CGN group was followed up for 12 months and divided into good prognosis group(n=79)and poor prognosis group(n=18)according to the prognosis results.Serum CHI3L1 and HSP60 levels were detected by enzyme-linked immunosorbent assay,and renal function indexes were detected by automatic biochemical analyzer.The correlation between CHI3L1,HSP60 and renal function indexes were analyzed.ROC analysis was used to evaluate the prognostic value of CHI3L1 and HSP60 in CGN patients.Results The serum levels of CHI3L1 and HSP60 in the CGN group were higher than those in the healthy group(P＜0.05).The blood urea nitrogen,creatinine,and uric acid levels in the CGN group and poor prognosis group were higher than those in the healthy group and good prognosis group,respectively(P＜0.05).The Pearson correlation analysis results showed that serum CHI3L1 and HSP60 were positively correlated with blood urea nitrogen,blood creatinine,and blood uric acid(P＜O.001).The combination of serum CHI3L1 and HSP60 has the highest efficacy in predicting the prognosis of CGN patients(P＜0.001).Conclusion Serum CHI3L1 and HSP60 levels were elevated in CGN patients,which can be used as potential biomarkers to predict the prognosis of patients.
万方数据
维普
